Combine chili powder, garlic powder, onion powder, red pepper flakes, oregano, smoked paprika, cumin, salt, and black pepper in a small bowl. Stir to mix well and set aside.

Heat a large nonstick skillet over medium. Add lean ground beef and cook until evenly browned. Drain excess grease.

Sprinkle seasoning over the beef, add salsa, and stir to combine. Transfer the seasoned beef to a bowl. Add shredded Pepper Jack cheese and stir until evenly coated.

Place 8 tortillas between damp paper towels. Microwave for 30 seconds to make them pliable and easier to roll.

Repeat with the remaining tortillas once ready.

Place a warm tortilla on a clean surface. Spoon 2 rounded tablespoons of the beef-and-cheese filling near the bottom third. Roll up tightly and place seam-side down on a baking sheet lined with foil or parchment. Repeat with remaining tortillas and filling.

Lightly mist the taquitos with cooking spray. Bake at 400°F for about 15 minutes, until tortillas are crisp and edges turn golden. Serve warm.